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Rapid and Specific Immunomagnetic Isolation of Mouse

Several in vitro studies have suggested that these galactolipids transduce developmental signals, facilitate protein trafficking and TY - THES. T1 - Myelin biogenesis. T2 - Dynamics of MBP, PLP and galactolipids. AU - Ozgen, Hande. PY - 2014.

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Mice with a disruption in the gene that encodes the biosynthetic enzyme UDP-galactose:ceramide galactosyl transferase (CGT) are incapable of synthesizing these lipids yet form myelin sheaths that exhibit major and minor dense lines with spacing comparable to controls. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipids transduce developmental signals, facilitate protein trafficking and TY - THES.

Mol … bodies raised against GalC inhibit myelination in vitro and in vivo31–34. Although these studies suggest a role for GalC in axoglial interactions, the nature of these interactions remains to be determined. Moreover, at T. Coetzee et al.– Myelin galactolipids REVIEW Fig. 1.

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A short summary of this paper. Myelination is a developmentally regulated process whereby myelinating glial cells elaborate large quantities of a specialized plasma membrane that ensheaths axons.

Rapporterade fall • Adrenoleukodystrofi - LookForDiagnosis

(1996). Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

126-127Artikel i tidskrift (Övrigt  (författare); Phosphate-deficient oat replaces a major portion of the plasma membrane phospholipids with the galactolipid digalactosyldiacylglycerol.
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Dessa ämnen är nödvändiga för näring av hjärnan, syntesen av myelin i nerver och för att upprätthålla en sund  Galactolipid förstörs lätt vid hög temperatur! Dessa ämnen är nödvändiga för näring av hjärnan, syntesen av myelin i nerver och för att upprätthålla en sund  Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these molecules play in the myelin sheath are not well understood. Until recently, our concept of GalC and sulfatide functions had been principally defined by immunological and chemical perturbation studies that implicate these lipids in oligodendrocyte differentiation, myelin formation, and myelin stability. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin.

1984-11-01 These observations indicate that FA2H is a myelination-associated gene.
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Mice with a disruption in the gene that encodes the biosynthetic enzyme UDP-galactose:ceramide galactosyl transferase (CGT) are incapable of synthesizing these lipids yet form myelin sheaths that exhibit major and minor dense lines with spacing comparable to controls. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin.